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General Information
DRAVPR ID DRAVPR0108
Name Tripartite motif-containing protein 5
Sequence
Sequence Length 493
Source Homo sapiens (Human)
UniProt ID Q9C035
Gene TRIM5
Activity Information
Target Organism No specific virus mentioned in the entry
Activity [Ref.17156811]TRIM5 exhibited potent antiretroviral activity.
Structure Information
Predicted Structure Download AF-Q9C035-F1
Modification ①The N-terminal is acetylation.②Phosphorylation of Ser at position 86.
Comment
Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV)。
Literature Information
Literature 1
Title TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
Pubmed ID 25127057
Author Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Münch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V.
Literature 2
Title Unique features of TRIM5alpha among closely related human TRIM family members.
Pubmed ID 17156811
Author Li X, Gold B, O'hUigin C, Diaz-Griffero F, Song B, Si Z, Li Y, Yuan W, Stremlau M, Mische C, Javanbakht H, Scally M, Winkler C, Dean M, Sodroski J.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.