DRAVPR ID  DRAVPR0109

Name   Tripartite motif-containing protein 5(TRIM5alpha)

Sequence  MASGILLNVKEEVTCPICLELLTEPLSLHCGHSFCQACITANHKKSMLYKEGERSCPVCRISYQPENIQPNRHVANIVEKLREVKLSPEEGQKVDHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKLQTALEMLRQKQQEAEKLEADIREEKASWKIQIDYDKTNVSADFEQLREILDWEESNELQNLEKEEEDILKSLTKSETEMVQQTQYMRELISELEHRLQGSMMDLLQGVDGIIKRIENMTLKKPKTFHKNQRRVFRAPDLKGMLDMFRELTDARRYWVDVTLAPNNISHAVIAEDKRQVSSRNPQIMYQAPGTLFTFPSLTNFNYCTGVLGSQSITSGKHYWEVDVSKKSAWILGVCAGFQSDAMYNIEQNENYQPKYGYWVIGLQEGVKYSVFQDGSSHTPFAPFIVPLSVIICPDRVGVFVDYEACTVSFFNITNHGFLIYKFSQCSFSKPVFPYLNPRKCTVPMTLCSPSS

Sequence Length  497

Source  Macaca mulatta (Rhesus macaque)

UniProt ID Q0PF16

Gene TRIM5

Target Organism  HIV-1

Activity 

• [Ref.18389079]Human immunodeficiency virus type 1(HIV-1):RhTRIM5α blocks early replication steps of HIV-1 and inhibits the replication.

PDB ID  2LM3  3UV9  4TKP  5K3Q 

Predicted Structure Download  AF-Q0PF16-F1

Modification  ①The N-terminal is acetylation.②Phosphorylation of Ser at position 87.

RhTRIM5α can restrics the replication of retroviruses such as HIV-1.

Literature 1

Title   The interferon response inhibits HIV particle production by induction of TRIM22.

Pubmed ID   18389079

Author   Barr SD, Smiley JR, Bushman FD.