General Information


DRAVPR ID  DRAVPR0112

Name   NFX1-type zinc finger-containing protein 1

Sequence 

Sequence Length  1909

Source  Mus musculus (Mouse)

UniProt ID Q8R151

Gene Znfx1



Activity Information


Target Organism  VSV, EMCV, SeV

Activity 

  • [Ref.31685995]vesicular stomatitis virus (VSV)/encephalomyocarditis virus (EMCV)/Senda virus (SeV): ZNFX1 directly binds to viral RNA and specifically restricts the replication of viruses.



Structure Information


PDB ID  None

Predicted Structure Download  AF-Q8R151-F1

';

Modification  No modifications on the sequence.



Comment


zinc finger NFX1-type containing 1 (ZNFX1), a helicase SF1, is an interferon (IFN)-stimulated, mitochondrial-localised dsRNA sensor that specifically restricts the replication of RNA viruses.



Literature Information


Literature 1

Title   Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.

Pubmed ID   31685995

Author   Wang Y, Yuan S, Jia X, Ge Y, Ling T, Nie M, Lan X, Chen S, Xu A.