DRAVPR ID  DRAVPR0114

Name   Interferon regulatory factor 3

Sequence  MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES

Sequence Length  427

Source  Homo sapiens (Human)

UniProt ID Q14653

Gene IRF3

Target Organism  SARS-CoV-2

Activity 

• [Ref.33440148]SARS-CoV-2:Activated upon coronavirus SARS-CoV-2 infection and regulate interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against viruse.

PDB ID  1J2F  1T2K  1ZOQ  2PI0  3A77  5JEL  6SJA  7JFL 

Predicted Structure Download  AF-Q14653-F1

Modification  ①Phosphorylation of Thr at position 3, 75, 180, 237, 244, 253, 404.②Phosphorylation of Ser at position 14, 97, 123, 175, 188, 385, 386, 396, 398, 427.③There is a disulfide bonds between Cys267 and Cys289.

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Literature 1

Title   MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

Pubmed ID   33440148

Author   Yin X, Riva L, Pu Y, Martin-Sancho L, Kanamune J, Yamamoto Y, Sakai K, Gotoh S, Miorin L, De Jesus PD, Yang CC, Herbert KM, Yoh S, Hultquist JF, García-Sastre A, Chanda SK.