General Information


DRAVPR ID  DRAVPR0116

Name   E3 ubiquitin-protein ligase TRIM11

Sequence 

Sequence Length  468

Source  Homo sapiens (Human)

UniProt ID Q96F44

Gene TRIM11



Activity Information


Target Organism  HIV-1

Activity 

  • [Ref.18248090]Human immunodeficiency virus type 1(HIV-1):TRIM11 inhibits the virus entry of HIV



Structure Information


PDB ID  None

Predicted Structure Download  AF-Q96F44-F1

';

Modification  Phosphorylation of Ser at position 85.



Comment


Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression.



Literature Information


Literature 1

Title   TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. 

Pubmed ID   18248090

Author   Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W.