General Information


DRAVPR ID  DRAVPR0120

Name   Interferon-induced protein with tetratricopeptide repeats 2

Sequence 

Sequence Length  472

Source  Mus musculus (Mouse)

UniProt ID Q64112

Gene Ifit2



Activity Information


Target Organism  VSV

Activity 

  • [Ref.22615570]vesicular stomatitis virus (VSV):Ifit2 protects mice from lethal intranasal VSV infection, Ifit2 suppresses replication of VSV in the brain after intranasal infection.



Structure Information


PDB ID  None

Predicted Structure Download  AF-Q64112-F1

';

Modification  The N-terminal is acetylation.



Comment


Ifit2 failed to protect mice from another neurotropic virus, encephalomyocarditis virus, nor was it necessary for protecting organs other than brain from infection by VSV.



Literature Information


Literature 1

Title   Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.

Pubmed ID   22615570

Author   Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, Diamond MS, Virgin HW, Sen GC.