DRAVPR ID  DRAVPR0123

Name   Tripartite motif-containing protein 15

Sequence  MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG

Sequence Length  465

Source  Homo sapiens (Human)

UniProt ID Q9C019

Gene TRIM15

Target Organism  MLV

Activity 

• [Ref.18248090]murine leukemia virus (MLV):TRIM15 interferes with MLV release by directly or indirectly binding the MLV Gag precursor protein via its B-box.

PDB ID  None

Predicted Structure Download  AF-Q9C019-F1

Modification  No modifications on the sequence.

The antiviral activity of TRIM15 depends on the ability of its B-box to Interact with the MLV Gag precursor protein.

Literature 1

Title   TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. 

Pubmed ID   18248090

Author   Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W.