DRAVPR ID  DRAVPR0130

Name   Scytovirin(SVN)

Sequence  GSGPTYCWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQGTSRKPDPGPKGPTYCWDEAKNPGGPNRCSNSKQCDGARTCSSSGFCQGTAGHAAA

Sequence Length  95

Source  Scytonema varium

UniProt ID P86041

Gene N/A

Target Organism  HIV

Activity 

• [Ref.12614152]Human immunodeficiency virus(HIV):The protein displayed potent anticytopathic activity against laboratory strains and primary isolates of HIV-1 with EC50 values ranging from 0.3 to 22 nM.

PDB ID  2JMV  2QSK  2QT4 

Predicted Structure Download  AF-P86041-F1

Modification  There are five disulfide bonds between Cys7 and Cys55, Cys20 and Cys32, Cys26 and Cys38, Cys68 and Cys80, Cys74 and Cys86.

Scytovirin binds to viral coat proteins gp120, gp160, and gp41 but not to cellular receptor CD4 or other tested proteins.

Literature 1

Title   A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium.

Pubmed ID   12614152

Author   Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC 2nd, Turpin J, Watson K, Buckheit RW Jr, Boyd MR.