To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0131
Name Mitochondrial antiviral-signaling protein
Sequence
Sequence Length 503
Source Mus musculus (Mouse)
UniProt ID Q8VCF0
Gene Mavs
Activity Information
Target Organism No specific virus mentioned in the entry
Activity [Ref.24037184]Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5)
Structure Information
PDB ID 4GHU
Predicted Structure Download AF-Q8VCF0-F1
Modification â‘ Phosphorylation of Ser at position 152, 157, 172, 186, 220, 251, 256, 384, 418.â‘¡The Arg at positio 234 indicates Asymmetric dimethylarginine.
Comment
No comments found in the entry
Literature Information
Literature 1
Title The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells
Pubmed ID 24037184
Author Liu Y, Lu N, Yuan B, Weng L, Wang F, Liu YJ, Zhang Z.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.