DRAVPR ID  DRAVPR0142

Name   HMGN2

Sequence  PKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKEGNNPAENGDAKTDQAQKAEGAGDAK

Sequence Length  89

Source  Human mononuclear leukocyte, H. sapiens

UniProt ID P05204

Gene HMGN2

Target Organism  HBV

Activity 

• [Ref:19150374]HBV:At the concentrations of HMGN2 protein (100, 20, 5, and 1 μg/ml), the reduction of HBsAg was after 144 h 31.6 ± 3.0%, 11.2 ± 1.8%, 6.0 ± 1.6%, 4.44 ± 1.3% after 72 h, and 36.9 ± 5.0%, 30.1 ± 4.1%, 17.8 ± 2.9%, 14.9 ± 2.8%, respectively. HBeAg decreased after 72 h to 66.7 ± 4.1%, 52 ± 2.8%, 40.8 ± 4.9% and 10.8 ± 2.7%, respectively, after 144 h to 68.6 ± 3.1%, 57.1 ± 4.9%, 42.1 ± 3.8% and 15.5 ± 1.8%, respectively

PDB ID  None

Predicted Structure Download  No predicted structure information available for the entry

Modification  No modifications on the sequence.

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Literature 1

Title   Inhibitory effect of HMGN2 protein on human hepatitis B virus expression and replication in the HepG2.2.15 cell line

Pubmed ID   19150374

Author   Feng Y, He F, Zhang P, Wu Q, Huang N, Tang H, Kong X, Li Y, Lu J, Chen Q, Wang B.