DRAVPR ID  DRAVPR0145

Name   eboIZN39IQ

Sequence  GHMDIKKEIEAIKKEQEAIKKKIEAIEKELRQLANETTQ(A/D)LQLFLR(A/D)TTELRTFSILNRK(A/D)IDFLLQRMKQIEDKIEEIESKQKKIENEIARIKKLIGERY

Sequence Length  102

Source  Synthetic construct

UniProt ID None

Gene Not Available

Target Organism  EBOV-Z

Activity 

• [Ref:25287718]EBOV:IC50 = 320 nM/IC67 = 10 microM.The peptide mimic eboIZN39IQ combats Ebola virus by targeting its highly conserved N-trimer region within the GP protein, crucial for viral entry. It interferes with prehairpin intermediate formation during fusion, impeding membrane fusion essential for viral entry, offering promise for novel antiviral strategies against Ebola.

PDB ID  None

Predicted Structure Download  No predicted structure information available for the entry

Modification  No modifications on the sequence.

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Literature 1

Title   Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets

Pubmed ID   25287718

Author   Clinton TR, Weinstock MT, Jacobsen MT