General Information


DRAVPR ID  DRAVPR0156

Name   HB36.6

Sequence 

Sequence Length  97

Source  IAV(H1N1)

UniProt ID None

Gene HA



Activity Information


Target Organism  IAV-H1N1

Activity  [Ref;26845438]Influenza A/California/2009 (H1N1) IC50 = 0.18 µg/mL, A/Puerto Rico/1934 (H1N1) IC50 = 0.58 µg/mL, A/New Caledonia/1999 (H1N1) IC50 = 1.26 µg/mL, A/Hong Kong/2003 (H5N1) IC50 = 12 µg/mL



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure information available for the entry

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Modification  No modifications on the sequence.



Comment


These changes in the sequence make HB36.6 present a much higher affinity with the HA segment of the influenza virus than its precursor



Literature Information


Literature 1

Title   A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

Pubmed ID   26845438

Author   P. S., Ward, A. B., Wilson, I. A., Dagley, A., Smee, D. F., Baker, D., & Fuller, D. H. (2016).