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General Information
DRAVPR ID DRAVPR0166
Name XCL1
Sequence
Sequence Length 93
Source CD8+ T cells, Homo sapiens
UniProt ID Q9HWT8
Gene Not Available
Activity Information
Target Organism HIV
Activity
Structure Information
PDB ID 2JPI
Predicted Structure Download No predicted structure information available for the entry
Modification Interestingly, introducing a disulfide bond between A36C and A49C mutants locks the chemokine conformation to the all-beta dimeric form (dubbed CC5), which is indeed a potent HIV inhibitor with high affinity to heparin
Comment
No comments found in the entry
Literature Information
Literature 1
Title Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1
Pubmed ID 26085164
Author Guzzo, C., Fox, J. C., Miao, H., Volkman, B. F., & Lusso, P. (2015).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.