DRAVPR ID  DRAVPR0167

Name   CXCL12

Sequence  KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK

Sequence Length  68

Source  Homo sapiens

UniProt ID P48061

Gene CXCL12, SDF1, SDF1A, SDF1B

Target Organism  HIV

Activity 

• [Ref:33872329]HIV:a CXCL12 variant that binds CXCR4 with comparable affinity compared to CXCL12 but does not internalize the receptor.resistance to CXCL12 originates from its reduced capacity to competitively inhibit virus binding to CXCR4.

PDB ID  2KOL 

Predicted Structure Download  No predicted structure information available for the entry

Modification  No modifications on the sequence.

No comments found in the entry

Literature 1

Title   Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis

Pubmed ID   33872329

Author   Armani-Tourret M, Zhou Z, Gasser R, Staropoli I, Cantaloube-Ferrieu V, Benureau Y, Garcia-Perez J, Pérez-Olmeda M, Lorin V, Puissant-Lubrano B, Assoumou L, Delaugerre C, Lelièvre JD, Lévy Y, Mouquet H, Martin-Blondel G, Alcami J, Arenzana-Seisdedos F, Izopet J, Colin P, Lagane B.