To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPs012
Peptide Name P21R8
Sequence LDLTYEMLSLQXVVKXLNESY
Sequence Length 21
Original Sequence DLTYEMASLQAVVKALNESY
Source Synthetic construct (From S2 unit of MERS-Cov)
Validation Experimentally Validated
Activity Information
Target Organism MERS-CoV
Assay Inhibition of MERS-CoV S-Protein-Mediated Cell–Cell Fusion Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The peptide inhibits MERS-CoV infection and its spike (S) protein-mediated cell–cell fusion.
Structure Information
Linear/Cyclic Cyclic
N-terminal Modification Acetylation
C-terminal Modification Carboxyamidation
Special Amino Acid and Stapling Position ①The 'X' at position 12 and 16 are R5 amino acids. ②X (12) and X (16) are cross-linked by hydrocarbon stapling.
Structure Description Not Available
Stereochemistry L
Literature Information
Literature 1
Title Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors
Pubmed ID 29442512
Reference Journal of medicinal chemistry, 61(5), 2018–2026.
Author Wang, C., Xia, S., Zhang, P., Zhang, T., Wang, W., Tian, Y., Meng, G., Jiang, S., & Liu, K. (2018).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.