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General Information
DRAVP ID DRAVPs023
Peptide Name CAI Stapled (Peptide 1)
Sequence ITFEDLLDYYGP
Sequence Length 12
Original Sequence ITFEDLLDYYGP
Source Synthetic Construct
Validation Experimentally Validated
Activity Information
Target Organism HIV-1
Assay Multi-Cycle Infection Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Capsid CTD and gp120
Mechanism CAI peptide binds to the C-terminal domain of HIV capsid protein as well as envelop glycoprotein gp120 with low micromolar binding affinities, and as a result, inhibits both the HIV-1 virus entry and the virus assembly.
Structure Information
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Special Amino Acid and Stapling Position Biphenyl staple (i+7)
Structure Description Not Available
Stereochemistry L
Literature Information
Literature 1
Title Design of antiviral stapled peptides containing a biphenyl cross-linker
Pubmed ID 24613163
Reference Bioorg Med Chem Lett. 2014 Apr 1;24(7):1748-51.
Author Muppidi A, Zhang H, Curreli F, Li N, Debnath AK, Lin Q.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.