DRAVP ID  DRAVPs031

Peptide Name   NYAD-36

Sequence  ISFR8ELLDYYS5ESGSc

Sequence Length  16

Original Sequence  ISFR8ELLDYYS5ESGSC

Source  Synthetic Construct

Validation   Experimentally Validated

Target Organism  HIV-1

Assay  Multi-Cycle Infection Assay

Activity 

• [Ref:24613163]HIV:IC50=1.5 ± 0.17μM in MT-2 cells, IC50=2.0 ± 0.4μM in TZM-b1 cells.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:24613163]HIV:CC50=>1189.4µM in MT-2 cells,CC50=>189.4µM in TZM b1 cells

Binding Target  Capsid CTD and gp128

Mechanism  Not Available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Special Amino Acid and Stapling Position  Hydrocarbon stapling occurs between R8 and S5: R8 = (R)-2-(7′-octenyl)alanine; S5 = (S)-2-(4′-pentenyl)alanine.

Structure Description  Not Available

Stereochemistry  L

Literature 1

Title   Design of antiviral stapled peptides containing a biphenyl cross-linker

Pubmed ID   24613163

Reference   Bioorg Med Chem Lett. 2014 Apr 1;24(7):1748-51.

Author   Muppidi A, Zhang H, Curreli F, Li N, Debnath AK, Lin Q.

DOI   10.1016/j.bmcl.2014.02.038