DRAVP ID  DRAVPs032

Peptide Name   SAH-HR2-D-PEGO-TC

Sequence  DISGINASVVNI8KEIDRLXEVAKNLNESLIDLQELG(K*)

Sequence Length  38

Original Sequence  DISGINASVVNIKEIDRLXEVAKNLNESLIDLQELG

Source  Synthetic Construct

Validation   Experimentally Validated

Target Organism  SARS-CoV

Assay  Pseudovirus Assay

Activity 

• [Ref:38177138]PV:IC50=1.2 × 10-7 in B.1.1.529.1 strain,SARS-CoV:IC50=1.6 × 10-6,LV:IC50=5.0 x 10-6 against Beta strain((B.1.351))

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Not Available

Linear/Cyclic  Cyclic

N-terminal Modification  Acetylation

C-terminal Modification  Free

Special Amino Acid and Stapling Position  Staple location is D and it is tricholeaterol with peg length is 0

Structure Description  Not Available

Stereochemistry  L

Literature 1

Title   A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

Pubmed ID   38177138

Reference   Nat Commun. 2024 Jan 4;15(1):274.

Author   Bird GH, Patten JJ, Zavadoski W, Barucci N, Godes M, Moyer BM, Owen CD, DaSilva-Jardine P, Neuberg DS, Bowen RA, Davey RA, Walensky LD.

DOI   10.1038/s41467-023-44361-1