General Information
DRAVP ID DRAVPe00021
Peptide Name NL6-L6A
Sequence TAYFLAKLAGRW
Sequence Length 12
UniProt ID No entry found
Source Synthetic construct(derived from HIV-1 integrase)
Activity Information
Target Organism HIV
Assay Integrase Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Integrase
Mechanism HIV-1 integrase (IN) is essential for viral replication. Following reverse transcription of the RNA into DNA by HIV-1 reverse transcriptase, IN integrates the viral DNA into the host genome.The peptide could inbibit integrase(By inhibiting the two steps of IN catalysis: 3′-processing and strand transfer).
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00021
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C68H101N17O15
Absent amino acids CDEHIMNPQSV
Common amino acids A
Mass 1396.65
Pl 9.99
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index -166
Hydrophobicity 34.17
Aliphatic Index 90
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 635.45
Polar residues 3
Literature Information
Literature 1
Title Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.
Pubmed ID 16854053
Reference J Med Chem. 2006 Jul 27;49(15):4477-86.
Author Li HY, Zawahir Z, Song LD, Long YQ, Neamati N.