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General Information
DRAVP ID DRAVPe00055
Peptide Name 4277(derived from DNA-polymerase domain of HIV-1 RT (20-mers))
Sequence DFRELNKRTQDFWEVQLGIP
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from HIV-1 Reverse Transcriptase)
Activity Information
Target Organism HIV
Assay Dot-blot assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Integrase
Mechanism Two viral encoded enzymes(reverse transcriptase and integrase) play central roles in the early stages of the replication of retroviruses and retrotransposons.The peptide derived from the RT DNA polymerase domain inhibits all three integrase-associated activities (3′-end processing, strand transfer, and disintegration) and inhibit virus replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00055
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C113H171N31O33
Absent amino acids ACHMSY
Common amino acids DEFLQR
Mass 2491.79
Pl 4.78
Basic residues 3
Acidic residues 4
Hydrophobic residues 7
Net charge -1
Boman Index -5871
Hydrophobicity -95.5
Aliphatic Index 73
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 289.47
Polar residues 3
Literature Information
Literature 1
Title Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.
Pubmed ID 15790559
Reference J Biol Chem. 2005 Jun 10;280(23):21987-96.
Author Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.