DRAVP ID  DRAVPe00067

Peptide Name   4317(derived from the RNase H domain of HIV-1 RT (20-mes))

Sequence  KTELQAIYLALQDSGLEVNI

Sequence Length  20

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from HIV-1 Reverse Transcriptase)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV

Assay  Dot-blot assay

Activity 

• [Ref.15790559]HIV-1:the level of peptide binding to HIV integrase is low

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Integrase

Mechanism  Two viral encoded enzymes(reverse transcriptase and integrase) play central roles in the early stages of the replication of retroviruses and retrotransposons.The peptide derived from the RNase H domain of HIV-1 RT inhibits integrase-associated activities (3′-end processing and strand transfer) and inhibit virus replication.

PDB ID  None

Predicted Structure Download  DRAVPe00067

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.

Pubmed ID   15790559

Reference   J Biol Chem. 2005 Jun 10;280(23):21987-96.

Author   Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A.

DOI   10.1074/jbc.M414679200