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General Information
DRAVP ID DRAVPe00067
Peptide Name 4317(derived from the RNase H domain of HIV-1 RT (20-mes))
Sequence KTELQAIYLALQDSGLEVNI
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from HIV-1 Reverse Transcriptase)
Activity Information
Target Organism HIV
Assay Dot-blot assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Integrase
Mechanism Two viral encoded enzymes(reverse transcriptase and integrase) play central roles in the early stages of the replication of retroviruses and retrotransposons.The peptide derived from the RNase H domain of HIV-1 RT inhibits integrase-associated activities (3′-end processing and strand transfer) and inhibit virus replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00067
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C99H164N24O33
Absent amino acids CFHMPRW
Common amino acids L
Mass 2218.53
Pl 4.14
Basic residues 1
Acidic residues 3
Hydrophobic residues 9
Net charge -2
Boman Index -1360
Hydrophobicity 19.5
Aliphatic Index 141.5
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 78.42
Polar residues 5
Literature Information
Literature 1
Title Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.
Pubmed ID 15790559
Reference J Biol Chem. 2005 Jun 10;280(23):21987-96.
Author Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.