To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00074
Peptide Name 4324(derived from the RNase H domain of HIV-1 RT (20-mes))
Sequence EQVDKLVSAGIRKVLFLDGI
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from HIV-1 Reverse Transcriptase)
Activity Information
Target Organism HIV
Assay Dot-blot assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Integrase
Mechanism Two viral encoded enzymes(reverse transcriptase and integrase) play central roles in the early stages of the replication of retroviruses and retrotransposons.The peptide derived from the RNase H domain of HIV-1 RT inhibits integrase-associated activities (3′-end processing and strand transfer) and inhibit virus replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00074
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C100H170N26O29
Absent amino acids CHMNPTWY
Common amino acids LV
Mass 2200.61
Pl 6.22
Basic residues 3
Acidic residues 3
Hydrophobic residues 10
Net charge 0
Boman Index -1582
Hydrophobicity 48.5
Aliphatic Index 146
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Literature Information
Literature 1
Title Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.
Pubmed ID 15790559
Reference J Biol Chem. 2005 Jun 10;280(23):21987-96.
Author Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.