To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00076
Peptide Name Vpr 15
Sequence LQQLLFIHFRIGCQH
Sequence Length 15
UniProt ID No entry found
Source Synthetic construct(HIV-1 gene product)
Activity Information
Target Organism HIV
Assay Luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Integrase
Mechanism IN is an essential enzyme for the stable infection of host cells because it catalyzes the insertion of viral DNA inside the pre-integration complex (PIC) into the genome of host cells in two successive reactions, designated as strand transfer and 3′-end-processing. The peptide could inhibit the activity of integrase and thus inhibit virus replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00076
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C86H133N25O19S
Absent amino acids ADEKMNPSTVWY
Common amino acids LQ
Mass 1853.22
Pl 8.27
Basic residues 3
Acidic residues 0
Hydrophobic residues 7
Net charge 3
Boman Index -808
Hydrophobicity 44.67
Aliphatic Index 130
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Peptide HIV-1 integrase inhibitors from HIV-1 gene products.
Pubmed ID 20586421
Reference J Med Chem. 2010 Jul 22;53(14):5356-60.
Author Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.