General Information

General Information

DRAVP ID DRAVPe00077

Peptide Name Env4-4

Sequence TNWLWYIKIFIMIV

Sequence Length 14

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HIV

Assay Luciferase assay

Activity

[Ref.20586421]HIV-1:inhibition of strand transfer catalyzed by integrase(IC50=1.9 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Integrase

Mechanism IN is an essential enzyme for the stable infection of host cells because it catalyzes the insertion of viral DNA inside the pre-integration complex (PIC) into the genome of host cells in two successive reactions, designated as strand transfer and 3′-end-processing. The peptide could inhibit the activity of integrase and thus inhibit virus replication.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00077

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C94H138N18O18S

Absent amino acids ACDEGHPQRS

Common amino acids I

Mass 1840.3

Pl 8.26

Basic residues 1

Acidic residues 0

Hydrophobic residues 9

Net charge 1

Boman Index 2373

Hydrophobicity 139.29

Aliphatic Index 160

Half Life

Mammalian:7.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 12490

Absorbance 280nm 960.77

Polar residues 3

Literature Information

Literature 1

Title Peptide HIV-1 integrase inhibitors from HIV-1 gene products.

Pubmed ID 20586421

Reference J Med Chem. 2010 Jul 22;53(14):5356-60.

Author Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H.

DOI 10.1021/jm1003528