DRAVP ID  DRAVPe00113

Peptide Name   P19(derived from E2 envelope protein of GB virus C)

Sequence  LPAFCQAIGWGDPITHWS

Sequence Length  18

UniProt ID  No entry found

Source  Synthetic construct(derived from E2 envelope protein of GB virus C)

Target Organism  HIV

Assay  Gp41-Mediated Cell-Cell Fusion Assay

Activity 

• [Ref.20718496]HIV-1:inhibition of gp41-induced cell-cell fusion in CEM-174 cells(IC50=369.5 μM);inhibition of HIV(HXB2) infection in TZM-bl Cells(IC50=46.0 μM);inhibition of HIV(BAL) infection in TZM-bl Cells(IC50=194.3 μM);inhibition of HIV(69-7) infection in TZM-bl Cells(IC50=71.4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  E2 GBV-C domain interferes with the HIV-1 fusion peptide-vesicle interaction, produce a notable decrease the cellular membrane fusion, and interfere with the HIV-1 infectivity in a dose-dependent manner.

PDB ID  None

Predicted Structure Download  DRAVPe00113

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Effect of synthetic peptides belonging to E2 envelope protein of GB virus C on human immunodeficiency virus type 1 infection.

Pubmed ID   20718496

Reference   J Med Chem. 2010 Aug 26;53(16):6054-63. 

Author   Herrera E, Tenckhoff S, Gómara MJ, Galatola R, Bleda MJ, Gil C, Ercilla G, Gatell JM, Tillmann HL, Haro I.

DOI   10.1021/jm100452c