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General Information
DRAVP ID DRAVPe00116
Peptide Name P23(derived from E2 envelope protein of GB virus C)
Sequence PITHWSHGQNRWPLSCPQ
Sequence Length 18
UniProt ID No entry found
Source Synthetic construct(derived from E2 envelope protein of GB virus C)
Activity Information
Target Organism HIV
Assay Gp41-Mediated Cell-Cell Fusion Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism E2 GBV-C domain interferes with the HIV-1 fusion peptide-vesicle interaction, produce a notable decrease the cellular membrane fusion, and interfere with the HIV-1 infectivity in a dose-dependent manner.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00116
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C96H138N30O25S
Absent amino acids ADEFKMVY
Common amino acids P
Mass 2144.4
Pl 8.68
Basic residues 3
Acidic residues 0
Hydrophobic residues 4
Net charge 3
Boman Index -3461
Hydrophobicity -110.56
Aliphatic Index 43.33
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 647.06
Polar residues 6
Literature Information
Literature 1
Title Effect of synthetic peptides belonging to E2 envelope protein of GB virus C on human immunodeficiency virus type 1 infection.
Pubmed ID 20718496
Reference J Med Chem. 2010 Aug 26;53(16):6054-63.
Author Herrera E, Tenckhoff S, Gómara MJ, Galatola R, Bleda MJ, Gil C, Ercilla G, Gatell JM, Tillmann HL, Haro I.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.