To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00156
Peptide Name P4
Sequence PTGERVWDRGNVTLLCDCPN
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from region of GB virus C glycoprotein E2)
Activity Information
Target Organism HIV
Assay Luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The possible mechanism of action is that the peptide could inhibit membrane fusion and inhibit HIV-1 replication in cells.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00156
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C94H149N29O31S2
Absent amino acids AFHIKMQSY
Common amino acids CDGLNPRTV
Mass 2245.51
Pl 4.56
Basic residues 2
Acidic residues 3
Hydrophobic residues 5
Net charge -1
Boman Index -4782
Hydrophobicity -59
Aliphatic Index 68
Half Life
Extinction Coefficient cystines 5625
Absorbance 280nm 296.05
Polar residues 8
Literature Information
Literature 1
Title Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.
Pubmed ID 21543477
Reference J Virol. 2011 Jul;85(14):7037-47.
Author Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.