DRAVP ID  DRAVPe00156

Peptide Name   P4

Sequence  PTGERVWDRGNVTLLCDCPN

Sequence Length  20

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from region of GB virus C glycoprotein E2)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV

Assay  Luciferase assay

Activity 

• [Ref.21543477]HIV-1(92UG024):inhibition of HIV replication in TZM-bl cells(IC50=15.07 μM);
• HIV-1(RU570):inhibition of HIV replication in TZM-bl cells(IC50=18.28 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  The possible mechanism of action is that the peptide could inhibit membrane fusion and inhibit HIV-1 replication in cells.

PDB ID  None

Predicted Structure Download  DRAVPe00156

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.

Pubmed ID   21543477

Reference   J Virol. 2011 Jul;85(14):7037-47.

Author   Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H. 

DOI   10.1128/JVI.02366-10