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General Information
DRAVP ID DRAVPe00157
Peptide Name P4-7
Sequence WDRGNVTLLCDCPNGPWVWV
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from region of GB virus C glycoprotein E2)
Activity Information
Target Organism HIV
Assay Luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The possible mechanism of action is that the peptide could inhibit membrane fusion and inhibit HIV-1 replication in cells.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00157
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C106H152N28O28S2
Absent amino acids AEFHIKMQSY
Common amino acids VW
Mass 2330.66
Pl 4.21
Basic residues 1
Acidic residues 2
Hydrophobic residues 8
Net charge -1
Boman Index -1482
Hydrophobicity -3.5
Aliphatic Index 82.5
Half Life
Extinction Coefficient cystines 16625
Absorbance 280nm 875
Polar residues 7
Literature Information
Literature 1
Title Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.
Pubmed ID 21543477
Reference J Virol. 2011 Jul;85(14):7037-47.
Author Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.