General Information

General Information

DRAVP ID DRAVPe00160

Peptide Name P6-1

Sequence TLLCDCPNGPWVWVPAFCQA

Sequence Length 20

UniProt ID No entry found

Source Synthetic construct(derived from region of GB virus C glycoprotein E2)

Activity Information

Target Organism HIV

Assay Luciferase assay

Activity

[Ref.21543477]HIV-1(92UG024):inhibition of HIV replication in TZM-bl cells(IC50=2.36 μM);
HIV-1(RU570):inhibition of HIV replication in TZM-bl cells(IC50=1.29 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target membrane

Mechanism The possible mechanism of action is that the peptide could inhibit membrane fusion and inhibit HIV-1 replication in cells.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00160

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C102H146N24O26S3

Absent amino acids EHIKMRSY

Common amino acids CP

Mass 2220.61

Pl 3.8

Basic residues 0

Acidic residues 1

Hydrophobic residues 9

Net charge -1

Boman Index 1049

Hydrophobicity 58.5

Aliphatic Index 78

Half Life

Mammalian:7.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 11125

Absorbance 280nm 585.53

Polar residues 6

Literature Information

Literature 1

Title Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.

Pubmed ID 21543477

Reference J Virol. 2011 Jul;85(14):7037-47.

Author Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H.

DOI 10.1128/JVI.02366-10