DRAVP ID  DRAVPe00162

Peptide Name   P6-2

Sequence  LCDCPNGPWVWVPAFCQAVG

Sequence Length  20

UniProt ID  No entry found

Source  Synthetic construct(derived from region of GB virus C glycoprotein E2)

Target Organism  HIV

Assay  Luciferase assay

Activity 

• [Ref.21543477]HIV-1(NL4-3):inhibition of HIV replication(IC50=2.3 μM);
• HIV-1(YU-2):inhibition of HIV replication(IC50=2.4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  The possible mechanism of action is that the peptide could inhibit membrane fusion and inhibit HIV-1 replication in cells.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.

Pubmed ID   21543477

Reference   J Virol. 2011 Jul;85(14):7037-47.

Author   Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H. 

DOI   10.1128/JVI.02366-10