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General Information
DRAVP ID DRAVPe00164
Peptide Name P6-4
Sequence PNGPWVWVPAFCQAVGWGDP
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from region of GB virus C glycoprotein E2)
Activity Information
Target Organism HIV
Assay Luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The possible mechanism of action is that the peptide could inhibit membrane fusion and inhibit HIV-1 replication in cells.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00164
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C105H139N25O25S
Absent amino acids EHIKLMRSTY
Common amino acids P
Mass 2183.47
Pl 3.8
Basic residues 0
Acidic residues 1
Hydrophobic residues 9
Net charge -1
Boman Index 891
Hydrophobicity 3.5
Aliphatic Index 53.5
Half Life
Extinction Coefficient cystines 16500
Absorbance 280nm 868.42
Polar residues 5
Literature Information
Literature 1
Title Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.
Pubmed ID 21543477
Reference J Virol. 2011 Jul;85(14):7037-47.
Author Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.