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General Information
DRAVP ID DRAVPe00202
Peptide Name VIRIP[A12]
Sequence LEAIPMSIPPEAKFNKPFVF
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from α1-antitrypsin)
Activity Information
Target Organism HIV
Assay ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide can inhibit HIV-1 entry by binding to the gp41 FP and preventing its insertion into the target cell membrane.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00202
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C110H167N23O27S
Absent amino acids CDGHQRTWY
Common amino acids P
Mass 2275.73
Pl 6.14
Basic residues 2
Acidic residues 2
Hydrophobic residues 9
Net charge 0
Boman Index -105
Hydrophobicity 27
Aliphatic Index 83
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide.
Pubmed ID 17448989
Reference Cell. 2007 Apr 20;129(2):263-75.
Author Münch J, Ständker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pöhlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.