To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00222
Peptide Name VIRIP[A13,C6,C11,F12]
Sequence LEAIPCSIPPCFAFNKPFVF
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from α1-antitrypsin)
Activity Information
Target Organism HIV
Assay ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide can inhibit HIV-1 entry by binding to the gp41 FP and preventing its insertion into the target cell membrane.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00222
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification Disulfide bond between Cys6 and Cys11
Stereochemistry L
Physicochemical Information
Formula C109H158N22O25S2
Absent amino acids DGHMQRTWY
Common amino acids FP
Mass 2240.71
Pl 5.99
Basic residues 1
Acidic residues 1
Hydrophobic residues 10
Net charge 0
Boman Index 1450
Hydrophobicity 93.5
Aliphatic Index 83
Half Life
Extinction Coefficient cystines 125
Absorbance 280nm 6.58
Polar residues 4
Literature Information
Literature 1
Title Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide.
Pubmed ID 17448989
Reference Cell. 2007 Apr 20;129(2):263-75.
Author Münch J, Ständker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pöhlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.