To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00300
Peptide Name Neutrophil defensin 2 (HNP-2, HP-2, HP2; Human, mammals, animals)
Sequence CYCRIPACIAGERRYGTCIYQGRLWAFCC
Sequence Length 29
UniProt ID P59665 P11479 Q14125 Q6EZF6 P59666 P11479 Q14125
Source Homo sapiens (Human)
Activity Information
Target Organism SARS-CoV-2
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
Predicted Structure Download DRAVPe00300
Linear/Cyclic Cyclic
N-terminal Modification Cyclization (N termini to C termini)
C-terminal Modification Cyclization (N termini to C termini)
Other Modification Disulfide bonds between Cys1 and Cys29,Cys3 and Cys18,Cys8 and Cys28.
Stereochemistry L
Physicochemical Information
Formula C147H223N43O37S6
Absent amino acids DHKMNSV
Common amino acids C
Mass 3377.01
Pl 8.67
Basic residues 4
Acidic residues 1
Hydrophobic residues 9
Net charge 3
Boman Index -3410
Hydrophobicity 24.83
Aliphatic Index 64.14
Half Life
Extinction Coefficient cystines 10345
Absorbance 280nm 369.46
Polar residues 13
Literature Information
Literature 1
Title Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.
Pubmed ID 34206990
Reference Viruses. 2021 Jun 26;13(7):1246.
Author Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.