To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00302
Peptide Name Neutrophil defensin 4 (Defensin, alpha 4; HNP-4, HP-4; Human, mammals, animals)
Sequence VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
Sequence Length 33
UniProt ID P12838
Source Homo sapiens (Human)
Activity Information
Target Organism SARS-CoV-2
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
PDB ID 1ZMM
Predicted Structure Download DRAVPe00302
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29.
Stereochemistry L
Physicochemical Information
Formula C157H261N49O43S6
Absent amino acids ADHKMPQW
Common amino acids C
Mass 3715.46
Pl 8.98
Basic residues 5
Acidic residues 1
Hydrophobic residues 11
Net charge 4
Boman Index -4636
Hydrophobicity 66.06
Aliphatic Index 91.21
Half Life
Extinction Coefficient cystines 1865
Absorbance 280nm 58.28
Polar residues 16
Literature Information
Literature 1
Title Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.
Pubmed ID 34206990
Reference Viruses. 2021 Jun 26;13(7):1246.
Author Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.