General Information


DRAVP ID  DRAVPe00305

Peptide Name   Metalnikowin-1 (Metalnikowin I; Insects, animals)

Sequence  VDKPDYRPRPRPPNM

Sequence Length  15

UniProt ID  P80408 

Source  Palomena prasina (Green shield bug) (Cimex prasinus)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>54.4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >54.4 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00305

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C80H128N26O22S

Absent amino acids  ACEFGHILQSTW

Common amino acids  P

Mass  1838.12

Pl  9.98

Basic residues  4

Acidic residues  2

Hydrophobic residues  1

Net charge  2

Boman Index  -6814

Hydrophobicity  -207.33

Aliphatic Index  19.33

Half Life 

  •     Mammalian:100 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  106.43

Polar residues  2



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09