General Information


DRAVP ID  DRAVPe00306

Peptide Name   Ranatuerin-9 (Frogs, amphibians, animals)

Sequence  FLFPLITSFLSKVL

Sequence Length  14

UniProt ID  P82824 

Source  Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=16.7 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:50% Cell death at 34.6 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00306

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C83H129N15O18

Absent amino acids  ACDEGHMNQRWY

Common amino acids  L

Mass  1625.03

Pl  8.75

Basic residues  1

Acidic residues  0

Hydrophobic residues  9

Net charge  1

Boman Index  2266

Hydrophobicity  175

Aliphatic Index  160

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09