General Information


DRAVP ID  DRAVPe00308

Peptide Name   DASamP2(D74,derived from polybia-MPI)

Sequence  IKWKKLLRAAKRIL

Sequence Length  14

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>57.6 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:50% Cell death at 1.3 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00308

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C83H149N25O15

Absent amino acids  CDEFGHMNPQSTVY

Common amino acids  K

Mass  1737.25

Pl  12.03

Basic residues  6

Acidic residues  0

Hydrophobic residues  8

Net charge  6

Boman Index  -2149

Hydrophobicity  -10.71

Aliphatic Index  153.57

Half Life 

  •     Mammalian:20 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  423.08

Polar residues  0



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09