General Information


DRAVP ID  DRAVPe00311

Peptide Name   Apidaecin IA (insect)

Sequence  GNNRPVYIPQPRPPHPRI

Sequence Length  18

UniProt ID  P35581 

Source  Apis mellifera L



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>47.7 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >47.4 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00311

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C95H150N32O23

Absent amino acids  ACDEFKLMSTW

Common amino acids  P

Mass  2108.44

Pl  11.71

Basic residues  4

Acidic residues  0

Hydrophobic residues  3

Net charge  4

Boman Index  -5356

Hydrophobicity  -140.56

Aliphatic Index  59.44

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  87.65

Polar residues  4



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09