General Information


DRAVP ID  DRAVPe00313

Peptide Name   Clavanin-B (His-rich; chordates, animals)

Sequence  VFQFLGRIIHHVGNFVHGFSHVF

Sequence Length  23

UniProt ID  P80711 

Source  Styela clava (Sea squirt)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=7.1 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:50% Cell death at 37.1 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00313

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C131H184N36O27

Absent amino acids  ACDEKMPTWY

Common amino acids  F

Mass  2695.13

Pl  9.75

Basic residues  5

Acidic residues  0

Hydrophobic residues  12

Net charge  5

Boman Index  -50

Hydrophobicity  75.22

Aliphatic Index  101.3

Half Life 

  •     Mammalian:100 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09