General Information


DRAVP ID  DRAVPe00319

Peptide Name   Misgurin (fish)

Sequence  RQRVEELSKFSKKGAAARRRK

Sequence Length  21

UniProt ID  P81474 

Source  Misgurnus anguillicaudatus



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>40.0 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >40.0 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00319

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C106H189N41O29

Absent amino acids  CDHIMNPTWY

Common amino acids  R

Mass  2501.92

Pl  11.84

Basic residues  9

Acidic residues  2

Hydrophobic residues  6

Net charge  7

Boman Index  -10445

Hydrophobicity  -163.81

Aliphatic Index  46.67

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09