General Information


DRAVP ID  DRAVPe00320

Peptide Name   D88 (frog)

Sequence  NLVSGLIEARKYLEQLHRKLKNRKV

Sequence Length  25

UniProt ID  No entry found

Source  Synthetic construct(derived from chain A of distinctin)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>33.3 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >33.3 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00320

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C134H233N43O35

Absent amino acids  CDFMPTW

Common amino acids  L

Mass  3006.59

Pl  10.55

Basic residues  8

Acidic residues  2

Hydrophobic residues  9

Net charge  6

Boman Index  -6725

Hydrophobicity  -74.4

Aliphatic Index  120.8

Half Life 

  •     Mammalian:1.4 hour
  •     Yeast:3 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  62.08

Polar residues  5



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09