General Information


DRAVP ID  DRAVPe00330

Peptide Name   Maximin H5

Sequence  ILGPVLGLVSDTLDDVLGIL

Sequence Length  20

UniProt ID  No entry found

Source  Bombina maxima



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>49.4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >49.7 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00330

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C93H160N20O29

Absent amino acids  ACEFHKMNQRWY

Common amino acids  L

Mass  2022.41

Pl  3.42

Basic residues  0

Acidic residues  3

Hydrophobic residues  11

Net charge  -3

Boman Index  2217

Hydrophobicity  148

Aliphatic Index  199.5

Half Life 

  •     Mammalian:20 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09