General Information


DRAVP ID  DRAVPe00333

Peptide Name   GF-17−

Sequence  GFNEIVQDIEDFLQNLV

Sequence Length  17

UniProt ID  No entry found

Source  Synthetic construct(derived from LL-37)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>25.1 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >25.1 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00333

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C90H137N21O30

Absent amino acids  ACHKMPRSTWY

Common amino acids  DEFILNQV

Mass  1993.2

Pl  3.43

Basic residues  0

Acidic residues  4

Hydrophobic residues  8

Net charge  -4

Boman Index  -2076

Hydrophobicity  12.94

Aliphatic Index  125.88

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09