General Information


DRAVP ID  DRAVPe00334

Peptide Name   DRS S9

Sequence  GLRSKIWLWVLLMIWQESNKFKKM

Sequence Length  24

UniProt ID  No entry found

Source  Synthetic construct(derived from Dermaseptin S9)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=31.6 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >32.9 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00334

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C145H228N36O31S2

Absent amino acids  ACDHPTY

Common amino acids  KL

Mass  3035.75

Pl  10.46

Basic residues  5

Acidic residues  1

Hydrophobic residues  11

Net charge  4

Boman Index  -1374

Hydrophobicity  -1.25

Aliphatic Index  109.58

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  16500

Absorbance 280nm  717.39

Polar residues  4



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09