General Information


DRAVP ID  DRAVPe00336

Peptide Name   GLK-19

Sequence  GLKKLLGKLLKKLGKLLLK

Sequence Length  19

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>47.5 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:50% Cell death at 25.1 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00336

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C102H194N26O20

Absent amino acids  ACDEFHIMNPQRSTVWY

Common amino acids  L

Mass  2104.82

Pl  10.78

Basic residues  7

Acidic residues  0

Hydrophobic residues  9

Net charge  7

Boman Index  825

Hydrophobicity  30

Aliphatic Index  184.74

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09