General Information


DRAVP ID  DRAVPe00340

Peptide Name   Maculatin-1.3 (frog, amphibia, animals)

Sequence  GLLGLLGSVVSHVVPAIVGHF

Sequence Length  21

UniProt ID  No entry found

Source  Litoria eucnemis (Australian anurans)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=4.0 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:50% Cell death at 8.02 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00340

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C98H159N25O24

Absent amino acids  CDEKMNQRTWY

Common amino acids  V

Mass  2071.49

Pl  6.92

Basic residues  2

Acidic residues  0

Hydrophobic residues  12

Net charge  2

Boman Index  3723

Hydrophobicity  162.38

Aliphatic Index  166.67

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09