General Information


DRAVP ID  DRAVPe00342

Peptide Name   D94 (bacteria)

Sequence  GAWKNFWSSLRKGFYDGEAGRAIRR

Sequence Length  25

UniProt ID  No entry found

Source  Synthetic construct(derived from chain A of plantaricin JK)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>34.1 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >34.1 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00342

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C133H198N42O34

Absent amino acids  CHMPQTV

Common amino acids  GR

Mass  2929.3

Pl  10.93

Basic residues  6

Acidic residues  2

Hydrophobic residues  9

Net charge  4

Boman Index  -7024

Hydrophobicity  -93.2

Aliphatic Index  43.2

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  12490

Absorbance 280nm  520.42

Polar residues  8



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09