General Information


DRAVP ID  DRAVPe00346

Peptide Name   D98 (frog,derived from temporin-LTc)

Sequence  SLSRFLRFLKIVYRRAF

Sequence Length  17

UniProt ID  No entry found

Source  Synthetic construct(derived from temporin-LTc)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=0.83 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:50% Cell death at 8.6 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00346

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C104H166N30O21

Absent amino acids  CDEGHMNPQTW

Common amino acids  R

Mass  2172.65

Pl  12.01

Basic residues  5

Acidic residues  0

Hydrophobic residues  9

Net charge  5

Boman Index  -3770

Hydrophobicity  32.35

Aliphatic Index  114.71

Half Life 

  •     Mammalian:1.9 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  93.13

Polar residues  3



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09