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General Information
DRAVP ID DRAVPe00352
Peptide Name Maculatin-1.1
Sequence GLFGVLAKVAAHVVPAIAEHF
Sequence Length 21
UniProt ID P82066
Taxon ID None
Source Litoria genimaculata (Green-eyed tree frog)
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The peptide could prevent HIV infection by disrupting the integrity of the virion membrane, and inhibit the transfer of HIV from DCs to T cells.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00352
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C103H160N26O24
Absent amino acids CDMNQRSTWY
Common amino acids A
Mass 2146.56
Pl 6.92
Basic residues 3
Acidic residues 1
Hydrophobic residues 14
Net charge 2
Boman Index 2613
Hydrophobicity 130
Aliphatic Index 134.76
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.
Pubmed ID 16140737
Reference J Virol. 2005 Sep;79(18):11598-606.
Author VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.